Associate Director / Director – Medicinal Chemistry
Pharmaron
Hoddesdon, UK
3d ago

We offer :

  • Vibrant and dynamic employment - we are a highly specialised, growth company operating in a critical sector of the economy - our future is strong and exciting
  • Opportunities to develop your skills and yourself - our rapid growth brings greater opportunities for you to learn and grow faster!
  • A great team where we all support each other - enjoy your work - after all you spend about a third of your time here!
  • Our Company : "We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world's leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges".

    We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity.

    We take pride in our professionalism and commitment to always deliver our very best work.

    We are based in Hertfordshire, in the town of Hoddesdon. The Hoddesdon campus, consisting of several purpose built scientific and administrative buildings together with a purpose built conference STE area has more than 5,000m2 of premier R&D space and houses an established Process Chemistry, Analytical Chemistry and Drug Discovery team, and a newly formed Formulation Development department.

    The Hoddesdon site has state-of-the-art Good Manufacturing Practice (GMP) standard facilities for the development of Active Pharmaceutical Ingredients (API), formulation development and process chemistry.

    We offer our employees a highly supportive team-work environment, enabling them to develop and liberate their true potential.

    Pharmaron Drug Discovery

    The Drug Discovery department, based in Hoddesdon, Hertfordshire, UK provides world-class drug discovery leadership to our partners in the life-science industry.

    As trusted collaborators, and in synergy with the capabilities and resources of the global Pharmaron group, this multi-disciplinary science team delivers quality, small-molecule preclinical candidates across a diversity of therapeutic areas and routes of administration.

    The experienced Hoddesdon team provides leadership, strategy, molecule design and project oversight and coupled with the deep expertise of Pharmaron worldwide platforms for experimental delivery we have created a unique service model that has quickly gained traction within the industry.

    Job Title : Associate Director / Director Medicinal Chemistry

    Job Summary

    With a rapidly expanding department and portfolio the Medicinal Chemistry function is seeking individuals who have a passion for leading Medicinal Chemistry science in discovery projects and who can strengthen the capabilities of our research teams.

    This is a rare and exciting opportunity for an inspiring, experienced and forward-thinking Medicinal Chemistry Leader to provide effective medicinal chemistry expertise and leadership of integrated small molecule drug discovery program to enhance the scientific reputation and business performance of Pharmaron.

    To develop and support a culture of respected science, best scientific practice, knowledge expansion and sharing.

    The Associate Director / Director Medicinal Chemistry role combines scientific decision-making and organisational leadership to advance small molecule drug discovery campaigns from hit identification through to development candidate.

    With a strong background in medicinal chemistry, including extensive knowledge of synthetic chemistry strategies, you will be recognised as an expert who is innovative and proactive in shaping work and influencing its direction and strategy, contributing the advancement of Pharmaron projects by providing synthetic and medicinal chemistry expertise and representing Pharmaron where appropriate with client partners, collaborators, regulatory authorities and other bodies as required.

    Key Roles and Responsibilities :

  • Ensure successful project and contractual deliverables, from hit-finding to candidate selection of high-quality candidate molecules.
  • Provide clear programme strategy and timely, efficient delivery of candidate molecules of exceptional quality through scientific rigour and high-quality compound design, to enable testing of clear hypotheses.
  • Ensure effective collaboration with client team, Pharmaron Discovery team and across other Pharmaron functions and sites to enhance programme delivery and efficiency.
  • Ensure open, timely and transparent communication of program results, plans, strategy and achievements to internal stakeholders including local and global Senior Management.
  • To provide support the scientific and operational needs of the department by development of new skills and assume responsibility for new capabilities.
  • Represent Pharmaron with the highest professional standards in client interactions, at scientific conferences, business development events, etc.
  • Continuously lead and manage the team using the performance review system to elevate performance and engagement throughout the team such that collectively and individually, potential is fully realised.
  • Ensure high calibre scientists are recruited into the department and receive appropriate training and mentoring. Support the leadership of the department and more junior staff in business and professional development

  • Some travel to Pharmaron sites in China and to partner sites will be required.
  • Qualification

    Qualifications, Knowledge & Skills

    Essential Requirements :

  • PhD degree in the area of Organic Chemistry or equivalent industrial experience
  • Multi-year experience in world-class small molecule drug discovery organisation(s) with a track record of delivery
  • Demonstrable leadership within small molecule drug discovery programs. Preferably with demonstrable delivery of development compounds that have moved into and through human clinical trials.
  • Track-record of scientific publications (papers, patents and posters / oral presentations) commensurate with experience.

  • Scientific leadership of multidisciplinary teams.
  • Managing external collaborations.
  • Working across multiple therapeutic areas.
  • Outstanding knowledge of medicinal chemistry, including the use of structural information, physicochemical properties and multiple parameter optimisation in compound design.
  • Knowledge of toxicology, DMPK and chemical concepts relevant to decision making and drug design.
  • Up-to-date knowledge of modern synthetic organic chemistry.
  • Why Should You Apply?

  • This is an opportunity for you as a successful Medicinal Chemistry leader to directly influence a variety of projects and experience a diversity of approaches and therapy areas being progressed by our Biotech and Pharma partners.
  • You will be a highly valued member of our team and have a real impact in a fast-growing and highly respected CRO striving to become the world leader in contract research services.

  • Build and shape your career in an environment that sets and commits to the highest standards of scientific research
  • To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do
  • Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2003, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development.

    With operations in China, US and UK staffed by over 12,000 employees, Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan and China

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