Senior Bioinformatician/ Data Scientist - Defining the genetic drivers of cancer
Wellcome Trust Sanger Institute
Hinxton, Cambridgeshire, GB
13d ago

Salary in the region of £36,737 - £44,451 (dependent on experience) plus excellent

Permanent / Open Contract

We seek a talented and highly motivated data scientist / bioinformatician to play a crucial role in new research on cancer mutations at the Wellcome Sanger Institute within the COSMIC group ().

The Opportunity

We have started a new project aiming to characterise every genetic mutation in every form of cancer, to define - at high-

resolution across global populations - the important events which are driving disease. We aim to take a very broad approach across millions of variants and hundreds of cancer disease types, to identify which variants act as drivers of disease, based on their biological and biochemical properties, then correlate how they work together to cause disease progression.

As this information is vital for use in pharmaceutical and clinical applications, we have partnered with AstraZeneca on this project, working closely with their Oncology division, and therefore this research will impact directly on the discovery and development of new precision medicines.

The results of this project will be available to the scientific community through COSMIC resources, and will offer multiple opportunities for very citeable publications.

About you

You will work together with COSMIC science team, bringing data science expertise to this project. The resources of COSMIC, the world’s largest and most detailed database of cancer mutations will be available to you, including unlimited access to HPC facilities.

Within the Sanger Institute, you will have also access to global specialists in genomics with decades of experience discovering new disease genes, who are already exploring these data.

About us

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists.

Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health.

We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

COSMIC

A revolution is underway in health informatics, with genetics increasingly important in understanding human health and disease.

COSMIC (), a database of genetic mutations in cancer, is a major resource in cancer research, used by over 4000 scientists every day across the informatics, diagnostic and pharmaceutical industries.

We are expanding rapidly and developing a range of new services to support multiple academic and industrial research efforts.

Essential Skills

MSc in Bioinformatic or Computer Science discipline (or equivalent experience)

  • Highly self-motivated, able to work independently and organise own workload
  • Excellent communication and effective team-working skills
  • Data handling and analysis skills
  • Experience of developing software
  • Ideal Skills

  • Good communication and presentation skills
  • Experience of developing software for scientific research
  • Familiarity with machine learning methods
  • Knowledge of human or cancer genetics
  • Other information

    The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists.

    Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health.

    We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

    Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

    Our Campus : Set over 125 acres , the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData.

    It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

    Our Benefits : Our employees have access to a comprehensive range of benefits and facilities including :

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service
  • Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

    Please include a covering letter and CV with your application. C losing date for applications : 24th April 2019

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