Associate Principal Scientist - Process Modelling
Macclesfield, England
1d ago

Are you a scientific leader who want to drive process modelling and simulation in process development and optimisation? Would you like to apply your expertise to impact the Chemical Development in a company that follows the science and changes the life of patients all over the world?

Then AstraZeneca might be the one for you!

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide.

Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Welcome to Macclesfield one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day.

To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you : gym access, networking events both in form of after-works and lunch & learns.

We also offer you a sustainable office working environment which is bright and spacious.

Your Business Area

In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients.

We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients (APIs) of our medicines in a sustainable, commercially viable way.

We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the latest technologies and principles in the processes we develop.

Our ambition is to establish a strong data driven, prediction, modelling, and simulation culture within the department to carry out our research and experimental work in the most efficient way and maximise learning from data generated.

To achieve our bold ambition, we have an open position for an Associate Principle Scientist in Process Modelling.

What you’ll do

In this role you will be a scientific leader who will drive process modelling and simulation in process development and optimisation.

This to establish strong modelling and predictive culture in our growing Chemical Development. You will work across skillset areas (eg.

Process engineering, chemistry, computational chemistry and crystallisation). Your role includes to identify and build on opportunities to apply modelling and simulation into our ways of working.

You will feed into the development projects and work closely with the project technical teams, to apply digital approaches to the process design and optimisation resulting in robust and sustainable chemical processes to manufacture APIs.

Key Responsibilities :

  • Deliver high quality to late stage drug substance development projects (Phase 2 onwards)
  • Investigate novel algorithms and techniques to answer relevant challenges in drug substance process design and optimisation
  • Develop, validate and implement modelling protocols to be used by general the wider scientific community
  • Drive and champion digital transformation and innovation within Chemical Development
  • Drive scientific excellence internally and externally by presenting current and novel approaches at scientific conferences and authoring scientific publications
  • Identify and build on opportunities for external scientific collaborations, collaboration with software vendors and lead collaboration projects
  • Work across subject areas and skill groups within and outside Chemical Development
  • Be a role model and mentor to scientists with less experience
  • Develop training material and provide training to AstraZeneca user groups
  • Essential for the role

    You have a degree or PhD in a relevant area such as, chemical engineering, chemistry or similar. You need a strong understanding of engineering principles of unit operations in chemical processes (e.

    g. mixing, distillation, liquid-liquid extraction, isolation and drying), and have experience of in-silico modelling of such operations.

    To succeed in your role, significant experience in flow sheeting modelling software such as gPROMs, Aspen Plus and / or others is a must.

    You have programming proficiency and experience with relevant software tools such as MATLAB, Python, R, Fortran, COMSOL, Pearl, C#, C++ and / or others.

    You are used to working and collaborating with colleagues with different skillsets. You also need experience working alongside R&D scientists (chemists, analysts, statisticians and crystallisation scientists).

    You are strategic person, both in your thinking and your approach. In this position your strong communication and influencing skills will be used daily.

    Preferred Requirements :

  • Experience in data curation - using tools such as (Git / Bitbucket)
  • Knowledge of server-based databases such as SQL or Oracle
  • Understanding and application of lab automation or control software
  • Experience working in the Pharmaceutical or Fine Chemicals Industry
  • Experience leading and driving improvement projects such as establishing new modelling and simulation approaches or ways of working
  • Experience of working with external partners such as academic or industry peers and / or software developers on investigating new modelling approaches and implementing these within the company
  • Understanding and application of machine learning, advanced data mining and analytics
  • Ability to use modelling software (e.g. Computational Fluid Dynamics, Discrete Element Method, DynoChem) to support process understanding
  • Knowledge and application of physical properties prediction methods such as COSMO-RS, NRTL, NRTL-SAC, UNIFAC, PC-SAFT, SAFT-g Mie
  • Knowledge of organic chemistry principles linking structure, properties and reactivity
  • Why AstraZeneca?

    At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.

    Delivering life-changing medicines to our patients is about being entrepreneurial - finding those moments and recognising their potential.

    Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be.

    This means we’re opening new ways to work, ground breaking cutting edge methods and bringing unexpected teams together.

    Are you ready to make a difference? Send in your application, and we’ll make it happen together!

    Please note that applications must include your current CV and a cover letter and be submitted before midnight on 26th April 2020 .

    AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

    We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

    We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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