Research Assistant in Developmental Genetics
University of Bath
Bath, England, GB
4d ago

Applications are invited for the post of Research Assistant in Developmental Genetics based in the Department of Biology & Biochemistry at the University of Bath, one of the UK’s most prestigious universities.

You will undertake research in a vibrant, inter-disciplinary research environment with an excellent international reputation.

You will work as a key member of an interdisciplinary research team investigating stem cell fate specification in vivo using zebrafish.

The project focuses on testing a revolutionary model of the mechanism controlling fate choice from progenitors in the neural crest.

This is an exciting BBSRC-funded collaboration between the University of Bath (Prof Robert Kelsh (Dept of Biology & Biochemistry) and Prof.

Jonathan Dawes (Dept of Mathematical Sciences) and the University of Surrey (Dr Andrea Rocco FHMS) utilising and developing a Systems Biology approach, with strong interactions between experimental and theoretical components.

Importantly, it builds on a substantial track record of interdisciplinary collaboration between our groups (e.g. Greenhill et al.

2011 PloS Genetics 7, e1002265; and Petratou et al., 2018, PLoS Genetics 14, e1007402)

You will be based in Prof. Kelsh's group (Bath), with a Research Fellow, and will be responsible for experimental aspects of the project, principally applying a combination of experimental approaches (including single cell transcriptomics, genetic fate-

mapping and timelapse monitoring of cell signalling in vivo) in zebrafish embryos to determine neural crest cell heterogeneity at single cell resolution, and to investigate how the gene regulatory network functions to allow fate choice in this system.

You will be expected to work closely with the groups of Prof. Dawes and Dr Rocco, providing experimental input to allow them to develop mathematical models of the network and its dynamics, to validate the dynamical models, and to inspire appropriate follow-up experiments.

Candidates for this post should have a BSc in Developmental Genetics or a related discipline, excellent microscopy and imaging skills, and be keen to work at the interface between mathematical modelling and biological sciences.

Experience of zebrafish genetic manipulation (e.g. CRISPRs, transgenesis), advanced in vivo imaging techniques, transcriptomics or epigenetics, neural crest development, and / or of working successfully in an interdisciplinary environment with mathematicians will be highly advantageous.

In addition to salary you will receive a generous annual leave entitlement and excellent development opportunities. The benefits package includes pension, childcare assistance and leisure facilities, and both the Department and the University are committed to providing a supportive and inclusive working environment.

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