Research Fellow/Senior Research Fellow - Bioinformatics
UCL
London, GB
3d ago

Duties and Responsibilities

We are seeking a collaborative and self-motivated Research Fellow / Senior Research Fellow on multi-omic analysis of pre-invasive squamous cell lung cancer as part of the Global Pre-cancer Atlas Challenge.

The successful candidate would be based at the newly renovated Lungs For Living laboratory under the guidance of Professor Janes.

Dr Nicholas McGranahan, based at the Cancer Institute would co-supervise.The project will focus on dissecting the mechanisms that allow a lung preinvasive (precancerous) lesion to invade and become squamous cell cancer, disentangling the temporal order of copy number alteration events that appear crucial in lesion progression and exploring the dynamic interplay between preinvasive cancer cells and the immune system.

Among other datasets, analysis will include utilizing next-generation sequencing (NGS) data from the preinvasive longitudinal squamous cell lung cancer patient cohort.

Further datasets include bulk and single cell RNAseq, epigenetic and spatial data.The role holder will work on bioinformatic analysis in the Lung for Living Research Centre, in collaboration with the team within the McGranahan lab as well as provide expert mathematical and statistical support.

Duration of the post is funded until 31 December 2022 in the first instance.

Key Requirements

The successful applicant will have a proven track record of publications, have previous experience with NGS data analysis, be fluent in at least one of the following programming languages : C++, Python or R, and is expected to have strong skills in the field of genomics and desirably one or more of the following : cancer biology, evolutionary biology, statistics, mathematics or machine learning.

Prior experience with data analysis based on integrating large datasets is particularly desired.

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