In- Vitro Scientist
CK Science
16d ago
  • Salary : £20 -£25 an hour
  • REF Number : 00044712
  • Consultant : Julie Marshall
  • Sector : Pharmaceutical
  • Discipline : Research And Development
  • Julie Marshall is recruiting for an In-Vitro Scientist to join a company in the Pharmaceutical industry at their site based in Cambridge on an initial 6 month contract basis.

    The Company :

    Our client is not afraid to do things differently. They're building a new kind of organisation to reset expectations of what a bio-

    pharmaceutical company can be. This means they're opening up new ways to work, groundbreaking, state of the art methods and bringing unexpected teams together.

    Location :

    Cambridge is a university city and the county town of Cambridgeshire, England, on the River Cam approximately 50 miles north of London.

    In the city that inspired great minds from Charles Darwin to Stephen Hawking, you'll find one of the world's oldest universities and plenty of historical culture.

    As well as this, Cambridge has plenty of nightlife, restaurants and something to suit all tastes. There is usually an event happening at one of Cambridge’s many entertainment venues on most nights of the week.

    The Role :

    As a member of a team within Drug Safety and Metabolism you will be responsible for the design, conduct and interpretation of in-

    vitro experiments to evaluate potential hepatotoxicity of candidate drugs. You will work closely with other safety scientists and discovery safety specialists to deliver optimised experimental approaches to identify and mitigate potential liver safety concerns across the portfolio.

    You will use your scientific knowledge and expertise to recommend appropriate experimental strategies, interpret data and develop the ongoing liver target organ strategy.

    In addition, you will : Design and deliver in vitro experimental data to support projects across the portfolio and in line with the liver organ strategy and mechanistic problem solving needed to derisk projects.

    Develop expertise in drug metabolism, biomarkers & 3D model technology with respect to the liver organ strategy.Develop scientific leadership to use in depth hepatic toxicological expertise and provide input into toxicology problem solving.

    Evaluation and validation of novel physiological hepatic models.Maintain understanding of Safety Assessment, the research and development process and how they contribute to achieving successful products.

    Use technical expertise and applies specialist knowledge to help projects.Build a specialist knowledge of one area of Safety Assessment (e.

    g. toxicology / drug metabolism / biomarkers / 3D model evaluation.Sharing experience, knowledge and industry developments with peer scientists.

    Interaction with senior and junior staff from all disciplines and areas, e.g. toxicologists, pathologists, DMPK scientists and project teams.

    Your Background :

    The ideal candidate for this role will have :

    MSc or equivalent or PhD level education (or equivalent training experience) in Toxicology, Pharmacology, Biomedical Science or related field.

    Experience of applying practical toxicology to address scientific questions.Develop innovative solutions and research proposals that address capability gaps in predictive safety science.

    Strong laboratory-based skills in molecular biology and / or in vitro cell-based models.Significant, direct experience in the design and execution of in vitro molecular biological, biochemical and / or cellular experiments to determine the effects of therapeutics on biological systems.

    Knowledge or experience in an area of liver biology, hepatic injury, drug metabolism would be preferred.Expertise in in-vitro approaches for assessment of liver safety / toxicity / drug metabolism is desirable.

    Experience of 3D cell culture or microphysiological systems would be beneficial.

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