Postdoctoral Researcher in Hematopoietic Lineage Commitment Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford Grade 7 : £32,817 - £40,322 per annum
This is an exciting opportunity for a highly motivated and ambitious Postdoctoral Researcher to join Professor Claus Nerlov at the MRC Weatherall Institute of Molecular Medicine (WIMM).
The Nerlov laboratory is world-leading in the study of hematopoietic stem- and progenitor cells, and the cellular pathways and molecular mechanisms that control their specification and differentiation.
In addition, they have described the mechanisms by which the normal hematopoietic differentiation process is subverted by leukemogenic mutations, such as those affecting C / EBPa and GATA-2.
The successful applicant will combine biochemical and genomic methodologies (gene editing, mass spectrometry, ATACseq, CUT&Tag, RNAseq) to study the role of GATA-2 in segregation of myeloid and erythroid lineages, with particular focus on the role of GATA-2 ZnF1 mutations in priming the progenitor compartment for subsequent development of erythroleukemia.
You will hold a PhD (or near to completion : thesis submitted) in a relevant area, together with relevant experience. A strong publication record in high-impact peer-reviewed journals is a prerequisite, as is the ability to work independently and as part of a team.
You will have excellent communication and organisational skills, with the ability to manage and independently drive, innovate and complete your own research and associated activities.
Computational experience in analysis of transcriptomic and epigenetic datasets is desirable.
This is a fixed term position, until 31 March 2022, funded by the Medical Research Council.