Duties and Responsibilities
Applications are invited for a Postdoctoral Research Fellow to join the Dubowitz Neuromuscular Centre, a well-funded, highly interactive research group led by Professor Francesco Muntoni.
The candidate will work on a multi-year highly innovative project looking at Brain Involvement iN Dystrophinopathies (BIND) funded by the EU Horizon 2020.
Dystrophinopathies are a group of neuromuscular diseases that are caused by mutations affecting the expression or function of the dystrophin protein.
While the disease primarily affects muscles, a significant proportion of patients have brain co-morbidities that significantly impact their quality of life.
This project will generate critical new knowledge that is needed to understand the brain functions of dystrophin and identify the associated molecular networks that underlie emotional, behavioural and cognitive co-morbidities affecting dystrophinopathy patients.
The candidate will perform immunoprecipitation coupled with tandem mass spectrometry to identify proteins that interact with dystrophin in different brain areas.
In addition, high-resolution imaging platforms will be used to precisely localize dystrophin and newly identified binding partners in the mouse and human brain.
In a second stage, the candidate will correlate anatomical and biochemical data with behavioural data to assess the role of dystrophin and its associated proteins in neural networks controlling behaviour, cognitive ability, memory and emotions.
Duration of the post is available until 31 December 2023 in the first instance.
We are looking for a highly motivated applicant with a PhD degree in neuroscience or a relevant subject. A strong background in protein analyses applied to the mammalian nervous system and experience with mouse work are highly desirable.
The ideal candidate should have experience in protein purification, immunoblotting, sub-cellular fractionation, dissection of brain areas, and / or immuno-histochemistry on brain sections.
Prior experience with proteomics and software for the analysis of protein / gene networks is desirable. Excellent verbal and written communication skills are required to communicate research findings in peer reviewed journals and scientific presentations.
The post-holder will work closely with existing staff at the Dubowitz Neuromuscular Centre but must have the ability to work independently.
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,542 - £33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.