The Rushden site is a centre of excellence for Radiolabelled Sciences incorporating both Metabolism (which includes Clinical Metabolism, Pre-clinical ADME, In vitro and DDI services, Large Molecule Metabolism, Environmental Fate and Plant Metabolism and Metabolite Identification) and Chemistry (which includes API and IMP manufacture).
The Metabolism team is Pharmaron’s global centre of excellence for drug and environmental metabolism. We partner with our clients to provide solutions in characterising a drug candidate’s ADME properties, kinetics, bioavailability and safety, as well as determining the fate of molecules in the environment and identifying the nature of residues in livestock and crops.
A passionate business with a strong appetite for growth and innovation, we are proud of our achievements to date and excited for what the future brings.
To continue our growth and success, we are seeking for a Senior Technical Specialist reporting to the team leader. The purpose of the role is to use expertise in High Resolution Mass Spectrometry to identify metabolites generated in studies for new product development based on global regulatory requirements.
Key Roles and Responsibilities :
Conduct analytical and metabolite identification work for both regulatory and non regulatory in-vitro, in-vivo, clinical and environmental-fate studies to successfully fulfil all the requirements of a study to the timelines stated in the Study Plan / Analytical Work Plan.
Responsible for the development of LC MS / MS chromatographic methods within the group and act as an expert consultant on the development of chromatographic methods within the wider Metabolism Department.
Increase the profile of the department externally through playing an active role as a subject matter expert in groups, networking and publications.
Manage technical training (writing and review of training materials) and maintenance of laboratory work standards in their area.
Mentor new Technical Specialists and other senior laboratory staff.
Provide technical advice to Study Directors / Management at all points in the study life cycle.
Hold equipment / software / lab space responsibilities on behalf of their team.
Actively contribute to client visits and teleconference as appropriate.
Work with Study Director on client communication, contributing scientifically to client discussions, as appropriate.
Initiate and maintain an active role in the implementation of new service level procedures as required, enhancing the service offerings of Pharmaron.
Interpret the relevant data and prepare accurate scientific study updates and study report sections.
Lead implementation of continuous improvement culture in specialist area proposing process improvement / new service offering initiatives to the Metabolism leadership team.
Keep up to date with technical developments in specialist area recommending new techniques and working with management to compile justification for Capex projects.
Address findings appropriate to area arising from QA audits and process inspections
Assist with performing scientific reviews of metabolite identification updates and report sections prepared by other members of the team
Assist with costing of metabolite identification work, in particular non-standard work, for specific projects through consultation with business development and team leader(s) as required
PhD, MSc or BSc (Hons) in Chemistry, Biochemistry or related subject
Experience in chromatographic method development
Expert in use of High Resolution Mass Spectrometers e.g. Waters Vion, Thermo Q-Exactive
Expert in relevant software e.g. Xcalibur, Waters UNIFY, Compound Discoverer.
Knowledge of metabolism / metabolic reactions
LC-MS / MS data interpretation skills
Experience with coaching and mentoring