Scientist II PRD (Downstream)
Oxford BioMedica
Oxford, GB
5d ago

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.

PR&D take processes from the laboratory bench scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Scientist II, Downstream to join the team. The purpose of this role is to perform process development studies for the purification of therapeutics for process understanding and characterisation.

Your responsibilities in this role would be :

  • Involvement in activities ranging from vector purification, process optimization, technology transfer, and process validation activities associated with the purification of new gene therapy vectors
  • Executing routine chromatographic purification activities with affinity, size exclusion and ion exchange media using ÄKTA systems (Unicorn software)
  • Performing bench scale filtration experimentations such as sterile membrane filtration, depth filtration and tangential flow filtration
  • Performing high-throughput purification studies and applying DOE methods to separations and (pre)formulation activities
  • Developing novel purification processes as well as using standard methods to purify viral vectors
  • Performing, developing and optimising robust, efficient, scalable strategies for improving process performance; including small-scale studies and pilot scale purification studies
  • Analysing and interpreting data, and presenting / documenting the results at meetings. Generating reports and preparing scientific presentations as needed
  • Writing and revising SOPs and technical reports
  • To be successful in this role, you will have the following skills and experience :

  • a graduate or postgraduate degree (or equivalent qualification) in a relevant scientific discipline
  • a sound understanding of basic purification principles and processes
  • fluency in written and spoken English
  • pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere is desirable
  • hands-on experience with the operation of laboratory, pilot or production scale ÄKTA purification systems
  • experience with cell culture
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